SMBA 1
Modify Date: 2024-01-08 20:39:04
SMBA 1 structure
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Common Name | SMBA 1 | ||
|---|---|---|---|---|
| CAS Number | 906440-37-7 | Molecular Weight | 315.322 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 502.0±38.0 °C at 760 mmHg | |
| Molecular Formula | C20H13NO3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 205.3±15.2 °C | |
Use of SMBA 1A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity. |
| Name | SMBA1 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity. |
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| References | References 1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935. 2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023. 3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012. 4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134. View Related Products by Target Bcl-2 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.0±38.0 °C at 760 mmHg |
| Molecular Formula | C20H13NO3 |
| Molecular Weight | 315.322 |
| Flash Point | 205.3±15.2 °C |
| Exact Mass | 315.089539 |
| LogP | 7.65 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.757 |
| RIDADR | NONH for all modes of transport |
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| 2-[(E)-(2-Nitro-9H-fluoren-9-ylidene)methyl]phenol |
| MFCD29079013 |
| Phenol, 2-[(E)-(2-nitro-9H-fluoren-9-ylidene)methyl]- |
| 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol |
| 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol |
| SMBA1 |