α-Helical CRF(9-41)

Modify Date: 2024-01-04 17:58:53

α-Helical CRF(9-41) Structure
α-Helical CRF(9-41) structure
Common Name α-Helical CRF(9-41)
CAS Number 90880-23-2 Molecular Weight 3826.40
Density N/A Boiling Point N/A
Molecular Formula C166H274N46O53S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-Helical CRF(9-41)


α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

 Names

Name α-Helical CRF(9-41)

 α-Helical CRF(9-41) Biological Activity

Description α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].
Related Catalog
Target

KB: ~100 nM (CRF2 receptor)[2] EC50: 140 nM (CRF1 receptor)[2]

References

[1]. Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6.

[2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.

 Chemical & Physical Properties

Molecular Formula C166H274N46O53S2
Molecular Weight 3826.40
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