Methapyrilene

Modify Date: 2024-01-11 09:40:50

Methapyrilene Structure
Methapyrilene structure
Common Name Methapyrilene
CAS Number 91-80-5 Molecular Weight 261.38600
Density N/A Boiling Point 173 - 175ºC at 3 mm Hg
Molecular Formula C14H19N3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methapyrilene


Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].

 Names

Name methapyrilene
Synonym More Synonyms

 Methapyrilene Biological Activity

Description Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
Related Catalog
In Vitro Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1].
In Vivo Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2]. Animal Model: Male Wistar derived AlpK:APfSD (Alderley Park) rats[2] Dosage: 50 mg/kg, 150 mg/kg Administration: Gavage with water (vehicle), daily, 3 days Result: Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg. Decreased levels of both glucose and glycogen in the liver. Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.

 Chemical & Physical Properties

Boiling Point 173 - 175ºC at 3 mm Hg
Molecular Formula C14H19N3S
Molecular Weight 261.38600
Exact Mass 261.13000
PSA 47.61000
LogP 2.71130

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT1400000
CHEMICAL NAME :
Pyridine, 2-((2-(dimethylamino)ethyl)-2-thenylamino)-
CAS REGISTRY NUMBER :
91-80-5
BEILSTEIN REFERENCE NO. :
0220729
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C14-H19-N3-S
MOLECULAR WEIGHT :
261.42
WISWESSER LINE NOTATION :
T6NJ BN2N1&1&1- BT5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - aggression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
182 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
77 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
375 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
100 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,420,1983

 Safety Information

RIDADR UN 1851
Packaging Group III
Hazard Class 6.1(b)

 Synonyms

Restryl
Thenylpyramine
N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine
Paradormalene
Methapyrilen
Semikon
Pyrinistol
Thionylan
Pyrinistab
Thenylene
metapyrilene
Tenalin
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