PYRILAMINE

Modify Date: 2026-07-06 18:13:52

PYRILAMINE structure	Common Name	PYRILAMINE
	CAS Number	91-84-9	Molecular Weight	285.38400
	Density	1.0141 (rough estimate)	Boiling Point	201ºC at 5 MM HG
	Molecular Formula	C₁₇H₂₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PYRILAMINE

Mepyramine, a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	mepyramine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0141 (rough estimate)
Boiling Point	201ºC at 5 MM HG
Molecular Formula	C₁₇H₂₃N₃O
Molecular Weight	285.38400
Exact Mass	285.18400
PSA	28.60000
LogP	2.65840
Index of Refraction	nD25 1.5760-1.5765
InChIKey	YECBIJXISLIIDS-UHFFFAOYSA-N
SMILES	COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0875000

CHEMICAL NAME :: Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-

CAS REGISTRY NUMBER :: 91-84-9

BEILSTEIN REFERENCE NO. :: 0269019

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C17-H23-N3-O

MOLECULAR WEIGHT :: 285.43

WISWESSER LINE NOTATION :: T6NJ DN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: OPHTAD Ophtalmologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.96- 1978- Volume(issue)/page/year: 143,154,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 714 ug/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

REFERENCE :: JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 160,4,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,131,1957 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 350 mg/kg

SEX/DURATION :: female 10-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1878- Volume(issue)/page/year: 164,138,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 50 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - stillbirth

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

1-bromomethyl-4...

CAS#:2746-25-0

PYRILAMINE

CAS#:91-84-9

Learn More

Literature: Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

4-Methoxybenzyl...

CAS#:824-94-2

PYRILAMINE

CAS#:91-84-9

Learn More

Literature: Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

2-Chloroethyldi...

CAS#:107-99-3

PYRILAMINE

CAS#:91-84-9

Learn More

Literature: Journal of the American Chemical Society, , vol. 68, p. 1999,2000 DE880749 , ; DRP/DRBP Org.Chem. US2502151 , ;

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:2746-25-0 1-bromomethyl-4... CAS#:824-94-2 4-Methoxybenzyl... CAS#:107-99-3 2-Chloroethyldi...
DownStream 1
CAS#:104499-47-0 N-(4-METHOXYBEN...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

[13C]-Pyrilamine

Neoantergan

Antalergan

N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine

Anhistabs

Pyranisamine

N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine

pyrilamine

Mepyramine(R)

Histapyran

Mepyramine

Mepiramine

Antallergan

Dorantamin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of mepyramine?

A: Related upstream materials(CAS) of mepyramine: 2746-25-0;824-94-2;107-99-3.

Q: What is the English name of mepyramine?

A: The English name of mepyramine is mepyramine.

Q: What is the polar surface area (PSA) of mepyramine?

A: Polar surface area (PSA) of mepyramine is 28.60000.

Q: What is the molecular weight of mepyramine?

A: Molecular weight of mepyramine is 285.38400.

Q: What is the CAS number of mepyramine?

A: CAS number of mepyramine is 91-84-9.

Q: What is the SMILES notation of mepyramine?

A: SMILES notation of mepyramine is COc1ccc(CN(CCN(C)C)c2ccccn2)cc1.

Q: What are the uses of mepyramine?

A: Main uses of mepyramine: Mepyramine, a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

Q: What is the LogP of mepyramine?

A: LogP of mepyramine is 2.65840.

Q: What is the molecular formula of mepyramine?

A: Molecular formula of mepyramine is C17H23N3O.

Q: What is the InChIKey of mepyramine?

A: InChIKey of mepyramine is YECBIJXISLIIDS-UHFFFAOYSA-N.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mepyramine
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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PYRILAMINE

Use of PYRILAMINE

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

PYRILAMINE | FAQ

PYRILAMINEfactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.