Indotecan(LMP400)

Modify Date: 2025-08-26 20:42:26

Indotecan(LMP400) Structure
Indotecan(LMP400) structure
Common Name Indotecan(LMP400)
CAS Number 915303-09-2 Molecular Weight 478.49400
Density N/A Boiling Point N/A
Molecular Formula C26H26N2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Indotecan(LMP400)


Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

 Names

Name indotecan
Synonym More Synonyms

 Indotecan(LMP400) Biological Activity

Description Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
Related Catalog
Target

IC50:300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].

References

[1]. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.

 Chemical & Physical Properties

Molecular Formula C26H26N2O7
Molecular Weight 478.49400
Exact Mass 478.17400
PSA 88.46000
LogP 2.61900

 Synonyms

3-[(Morpholine)-1-propyl]-5,3-dimethoxy-8,9-meth ylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline
UNII-BTA69L5M8D
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