H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH trifluoroacetate salt

Modify Date: 2024-01-04 13:57:56

H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH trifluoroacetate salt structure	Common Name	H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH trifluoroacetate salt
	CAS Number	91575-26-7	Molecular Weight	690.72600
	Density	1.67±0.1 g/cm3 (20 °C, 760 mmHg)	Boiling Point	N/A
	Molecular Formula	C₂₅H₄₂N₁₀O₁₁S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH trifluoroacetate salt

GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide.

Name	L-Cysteine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl
Synonym	More Synonyms

Description	GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Peptides
In Vitro	GRGDSPC is conjugated to acrylated dextran via thiol-acrylate reaction to regulate the interactions of human mesenchymal stem cells (hMSCs) with the photocrosslinkable hydrogels. To determine the conjugation kinetics and efficiency of GRGDSPC peptide to DEX-MAES16, various GRGDSPC concentrations (i.e., 5, 10 and 20 mg/1 g DEX-MAES16) are conjugated to the acrylated Dextran (DEX) macromer over time (0.25, 0.5, 1 and 3h) in PBS at pH 7.8 and the free thiol groups of unreacted peptides are quantified using Ellman’s assay. In addition, the reaction kinetics of the thiol-peptide to acrylated (DEX-MAES16) and methacrylated (DEX-HEMA16) macromers are compared. As early as 15 min conjugation, with 5, 10 and 20 mg of GRGDSPC peptide/1 g modified DEX, the peptide conjugation efficiencies with DEX-MAES are 105.40, 94.10 and 87.45%, respectively, while for the reaction with the DEX-HEMA they are 0.73, 15.78 and 18.42%, respectively. After 1h, the GRGDSPC conjugation with DEX-MAES is completed with the peptide concentration of 10 mg, but only 35.66% of the thiol groups of the peptide react with DEX-HEMA. The reaction kinetics are also monitored at 3 h of conjugation, and all of the 20 mg GRGDSPC peptide reacts with acrylated DEX compared to only 32.53% for the methacrylated DEX at this time point[1].
Kinase Assay	GRGDSPC at various concentrations (5, 10, 20 mg peptide/g DEX-MAES) is mixed with the 40% theoretical mono(2-acryloyloxyethyl) succinate (MAES) (16% actual)-modified DEX macromer solution containing 0.05% Igracure D-2959 for 0.25-3 h at room temperature to examine conjugation efficiency and kinetics. The peptide conjugation efficiency is determined using Ellman’s assay. In addition, conjugation efficiency of the peptide to acrylated DEX (DEX-MAES16) and methacrylated DEX (DEX-HEMA16) with similar degrees of acrylate and methacrylate modification, respectively, are compared[1].
References	[1]. Nguyen MK, et al. Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNAdelivery to hMSCs to enhance their osteogenic differentiation. J Mater Chem B. 2017 Jan 21;5(3):485-495.

Density	1.67±0.1 g/cm3 (20 °C, 760 mmHg)
Molecular Formula	C₂₅H₄₂N₁₀O₁₁S
Molecular Weight	690.72600
Exact Mass	690.27600
PSA	387.36000

L-Cysteine, N-[1-[N-[N-[N-(N2-glycyl-L-arginyl)glycyl]-L-α-aspartyl]-L-seryl]-L-prolyl]-

H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH

Glycyl-L-arginylglycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-cysteine

GRGDSPC

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GRGDSPC
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Nanjing Peptide Biotech Ltd
China
Product Name: H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH trifluoroacetate salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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Price: ￥700/1 mg

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