Ibafloxacin

Modify Date: 2024-01-08 06:25:10

Ibafloxacin Structure
Ibafloxacin structure
Common Name Ibafloxacin
CAS Number 91618-36-9 Molecular Weight 275.27500
Density 1.4g/cm3 Boiling Point 477.5ºC at 760mmHg
Molecular Formula C15H14FNO3 Melting Point N/A
MSDS N/A Flash Point 242.6ºC

 Use of Ibafloxacin


R835 is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.

 Names

Name Ibafloxacin
Synonym More Synonyms

 Ibafloxacin Biological Activity

Description R835 is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.
Related Catalog
In Vivo The pharmacokinetic behavior of R835 (Ibafloxacin) is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of R835 are determined by high-performance liquid chromatography with fluorescence detection. After IV injection R835 shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of R835 after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats[1].
Animal Admin Goats[1] Six Murciano-Granadina female goats 52 to 58 kg in body weight (BW) and 3 to 4 y of age are used. A 5% aqueous solution of R835 (Ibafloxacin) is prepared from the pure substance and sterilized. The solution is administered by the IV route as a single dose of 15 mg/kg BW. Blood samples (4 mL) are collected from the contralateral jugular vein into heparinized tubes at 0, 5, 10, 15, 30, and 45 min and at 1, 1.5, 2, 4, 6, 8, 10, 12, 24, 32, 48, and 72 h after drug administration. The samples are centrifuged at 1500× g for 15 min, and then the plasma is removed and stored at -45°C until assayed. Milk samples are collected before and at 1, 2, 4, 6, 12, 24, 32, 48, and 72 h after complete evacuation of the udder at each collection period. The concentration of R835 is measured in plasma and milk by a modified high-performance liquid chromatography (HPLC) method.
References

[1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6.

 Chemical & Physical Properties

Density 1.4g/cm3
Boiling Point 477.5ºC at 760mmHg
Molecular Formula C15H14FNO3
Molecular Weight 275.27500
Flash Point 242.6ºC
Exact Mass 275.09600
PSA 59.30000
LogP 2.65440
Index of Refraction 1.632

 Synthetic Route

~%

Ibafloxacin Structure

Ibafloxacin

CAS#:91618-36-9

Literature: Minnesota Mining and Manufacturing Company Patent: US4898945 A1, 1990 ;

 Synonyms

1H,5H-Benzo[ij]quinolizine-2-carboxylic acid,9-fluoro-6,7-dihydro-5,8-dimethyl-1-oxo
9-fluoro-6,7-dihydro-5,8-dimethyl-1-oxo-1h,5h-benzo[ij]quinolizine-2-carboxylic acid
Ibafloxacinum
R-835
6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
R835