MK-4965
Modify Date: 2025-08-25 00:15:55
MK-4965 structure
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Common Name | MK-4965 | ||
|---|---|---|---|---|
| CAS Number | 920035-77-4 | Molecular Weight | 426.26 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H13Cl2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-4965MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1]. |
| Name | 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloroph enoxy}-5-chlorobenzonitrile |
|---|
| Description | MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)[1] |
| References |
| Molecular Formula | C20H13Cl2N5O2 |
|---|---|
| Molecular Weight | 426.26 |
| Exact Mass | 425.04500 |
| PSA | 110.57000 |
| LogP | 5.01998 |
| InChIKey | KXDIHAQCVNNLIB-UHFFFAOYSA-N |
| SMILES | N#Cc1cc(Cl)cc(Oc2cc(OCc3[nH]nc4nc(N)ccc34)ccc2Cl)c1 |
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Name: Half life in Beagle dog at 10 mg/kg, po and 2 mg/kg, iv
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL1941763
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|
Name: Half life in Sprague-Dawley rat at 10 mg/kg, po and 3 mg/kg, iv
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1941762
|
|
Name: Plasma protein binding in HIV1 infected patient
Source: ChEMBL
Target: Plasma
External Id: CHEMBL1661358
|
|
Name: Cytotoxicity against human MT4 cells up to 8.3 uM
Source: ChEMBL
Target: MT4
External Id: CHEMBL1930129
|
|
Name: Plasma clearance in Sprague-Dawley rat at 10 mg/kg, po and 3 mg/kg, iv
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1941755
|
|
Name: Antiviral activity against Human immunodeficiency virus expressing wild type RT infec...
Source: ChEMBL
Target: Human immunodeficiency virus
External Id: CHEMBL1930128
|
|
Name: Selectivity ratio of IC50 for HIV1 isolate R8 reverse transcriptase K103N mutant to I...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1661350
|
|
Name: Plasma clearance in Beagle dog at 10 mg/kg, po and 2 mg/kg, iv
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL1941756
|
|
Name: Selectivity ratio of IC50 for HIV1 isolate R8 reverse transcriptase Y181C mutant to I...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1661351
|
|
Name: Resistant ratio of IC50 for HIV 1 reverse transcriptase Y181C mutant to IC50 for wild...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2150637
|
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