HS56
Modify Date: 2025-08-25 21:44:52
HS56 structure
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Common Name | HS56 | ||
|---|---|---|---|---|
| CAS Number | 922050-57-5 | Molecular Weight | 317.751 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H8ClN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HS56HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM); displays a high degree of selectivity for DAPKs and Pims against a panel of 468 kinases, with only two off-target interactions TYK2 and GAK; also displays no significant inhibition or activation of nicotinic, adrenergic, or muscarinic receptors at 10 uM; HS56 delayed force onset, decreased contractile force, and reduced LC20 phosphorylation in excised rat caudal arterial VSM tissues, lowers blood pressure in spontaneously hypertensive mice without affecting heart rate. |
| Name | HS56 |
|---|
| Description | HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM); displays a high degree of selectivity for DAPKs and Pims against a panel of 468 kinases, with only two off-target interactions TYK2 and GAK; also displays no significant inhibition or activation of nicotinic, adrenergic, or muscarinic receptors at 10 uM; HS56 delayed force onset, decreased contractile force, and reduced LC20 phosphorylation in excised rat caudal arterial VSM tissues, lowers blood pressure in spontaneously hypertensive mice without affecting heart rate. |
|---|---|
| References | References 1. Carlson DA, et al. Cell Chem Biol. 2018 Jul 4. pii: S2451-9456(18)30220-4. View Related Products by Target Pim DAPK |
| Molecular Formula | C13H8ClN5OS |
|---|---|
| Molecular Weight | 317.751 |
| InChIKey | DRTDDTWOOFJKOH-UHFFFAOYSA-N |
| SMILES | N#CCSc1nc2c(cnn2-c2cccc(Cl)c2)c(=O)[nH]1 |