(E)-ajoene

Modify Date: 2024-01-09 17:40:31

(E)-ajoene Structure
(E)-ajoene structure
Common Name (E)-ajoene
CAS Number 92284-99-6 Molecular Weight 234.40
Density 1.181±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 376.0±42.0 °C (760 mmHg)
Molecular Formula C9H14OS3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (E)-ajoene


(E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region[1][2].

 Names

Name Disulfide, 2-propen-1-yl (1E)-3-(2-propen-1-ylsulfinyl)-1-propen-1-yl
Synonym More Synonyms

 (E)-ajoene Biological Activity

Description (E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region[1][2].
Related Catalog
References

[1]. Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14(6):1033-1044.  

[2]. Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem Toxicol. 2014 Oct;72:1-7.  

 Chemical & Physical Properties

Density 1.181±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 376.0±42.0 °C (760 mmHg)
Molecular Formula C9H14OS3
Molecular Weight 234.40
Exact Mass 234.02100
PSA 86.88000
LogP 3.86790

 Synonyms

NSC 614554
(E)-Ajoene
Disulfide, 2-propenyl 3-(2-propenylsulfinyl)-1-propenyl, (E)-
Disulfide, 2-propenyl (1E)-3-(2-propenylsulfinyl)-1-propenyl