Jingzhaotoxin-III
Modify Date: 2025-09-26 17:44:22
Jingzhaotoxin-III structure
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Common Name | Jingzhaotoxin-III | ||
|---|---|---|---|---|
| CAS Number | 925463-91-8 | Molecular Weight | 3919.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C174H241N47O46S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Jingzhaotoxin-IIIJingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2]. |
| Name | Jingzhaotoxin-III |
|---|
| Description | Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2]. |
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| Related Catalog | |
| Target |
IC50: 348 nM (Nav1.5 Channels)[1] |
| References |
| Molecular Formula | C174H241N47O46S6 |
|---|---|
| Molecular Weight | 3919.45 |
| InChIKey | OKELXNUZHJLTAQ-UHFFFAOYSA-N |
| SMILES | CC1NC(=O)C(Cc2ccc(O)cc2)NC(=O)CNC(=O)C(CCCCN)NC(=O)C2CSSCC(NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(N)CC(=O)O)C(=O)NCC(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(CCCCN)C(=O)NC3CSSCC(NC1=O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(Cc1c[nH]c4ccccc14)C(=O)NCC(=O)NC(Cc1c[nH]c4ccccc14)C(=O)NC(C(=O)NC(C)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N1CCCC1C(=O)O)C(C)C)CSSCC(NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)CNC3=O)C(=O)N2 |