PAMP-12

Modify Date: 2025-08-25 16:20:19

PAMP-12 Structure
PAMP-12 structure
Common Name PAMP-12
CAS Number 929905-12-4 Molecular Weight 1619.91
Density N/A Boiling Point N/A
Molecular Formula C77H118N24O15 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PAMP-12


PAMP-12 is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1].

 Names

Name PAMP-12

 PAMP-12 Biological Activity

Description PAMP-12 is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1].
Related Catalog
References

[1]. Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330(4):1146-1152.

[2]. Chen E, et al. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology. 2021;160(5):1709-1724.

 Chemical & Physical Properties

Molecular Formula C77H118N24O15
Molecular Weight 1619.91
InChIKey XXTXSQXRVLRJNL-DYQOJKGJSA-N
SMILES CC(C)CC(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(N)Cc1ccccc1)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)O
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