CAY10526
Modify Date: 2024-01-23 16:18:26
CAY10526 structure
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Common Name | CAY10526 | ||
|---|---|---|---|---|
| CAS Number | 938069-71-7 | Molecular Weight | 311.151 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 561.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C12H7BrO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 293.5±30.1 °C | |
Use of CAY10526CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1]. |
| Name | cay10526 |
|---|---|
| Synonym | More Synonyms |
| Description | CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1]. |
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| Related Catalog | |
| References |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 561.7±50.0 °C at 760 mmHg |
| Molecular Formula | C12H7BrO3S |
| Molecular Weight | 311.151 |
| Flash Point | 293.5±30.1 °C |
| Exact Mass | 309.929932 |
| PSA | 74.77000 |
| LogP | 2.54 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.791 |
| 4-benzo(b)thiophen-2-yl-3-bromo-5-hydroxy-5H-furan-2-one |
| 4-(1-Benzothiophen-2-yl)-3-bromo-5-hydroxy-2(5H)-furanone |
| 2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy- |
| 4-(1-benzothiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one |