RN-1734

Modify Date: 2024-01-16 17:00:35

RN-1734 structure	Common Name	RN-1734
	CAS Number	946387-07-1	Molecular Weight	353.30800
	Density	1.228g/cm3	Boiling Point	445ºC at 760 mmHg
	Molecular Formula	C₁₄H₂₂Cl₂N₂O₂S	Melting Point	N/A
	MSDS	USA	Flash Point	222.9ºC

Use of RN-1734

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).IC50 value: 2.3 μM (hTRPV4), 5.9 μM (mTRPV4), IC50 = 3.2 μM (rTRPV4) Target: TRPV4in vitro: RN-1734 completely inhibits both ligand- and hypotonicity-activated TRPV4. In addition, RN-1734 is selective for TRPV4 in a TRP selectivity panel including TRPV1, TRPV3 and TRPM8, and could thus be a valuable pharmacological probe for TRPV4 studies. [1]

Name	2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
Synonym	More Synonyms

Description	RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).IC50 value: 2.3 μM (hTRPV4), 5.9 μM (mTRPV4), IC50 = 3.2 μM (rTRPV4) Target: TRPV4in vitro: RN-1734 completely inhibits both ligand- and hypotonicity-activated TRPV4. In addition, RN-1734 is selective for TRPV4 in a TRP selectivity panel including TRPV1, TRPV3 and TRPM8, and could thus be a valuable pharmacological probe for TRPV4 studies. [1]
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
References	[1]. Kato K, et al. Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: a study to elucidate the action points of acidosis and search for putative target molecules. Eur J Pharmacol. 2011 Aug 1;663(1- [2]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

References

[1]. Kato K, et al. Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: a study to elucidate the action points of acidosis and search for putative target molecules. Eur J Pharmacol. 2011 Aug 1;663(1-

[2]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.

Density	1.228g/cm3
Boiling Point	445ºC at 760 mmHg
Molecular Formula	C₁₄H₂₂Cl₂N₂O₂S
Molecular Weight	353.30800
Flash Point	222.9ºC
Exact Mass	352.07800
PSA	57.79000
LogP	4.86220
Index of Refraction	1.536
Storage condition	2-8℃

RN-1734 MSDS(Chinese)

RIDADR	NONH for all modes of transport

Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.

PLoS ONE 10 , e0128242, (2015)

Various transient receptor potential (TRP) channels in sensory neurons contribute to the transduction of mechanical stimuli in the colon. Recently, even the cold-sensing menthol receptor TRPM(melastat...

((2,4-dichlorophenyl)sulfonyl)(isopropyl)(2-((isopropyl)amino)ethyl)amine

RN-1734

DC Chemicals Limited
China
Product Name: RN-1734
Price: $450.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $66/10mM*1mLinDMSO

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RN-1734

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