CI 75300

Chemical FormulaC21H20O6
CAS Number94875-80-6

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Section II.Composition and Information on Ingredients
CAS Number Percent (%)TLV/PELToxicology Data
Chemical Name
Curcumin (Synthetic)Min. 98.0 (T) Not available.Rat LD50 (oral) 12.2gm/kg
94875-80-6
Mouse LD50 (oral) >2000mg/kg
Mouse LD50 (ipr) 1500mg/kg

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Section III. Hazards Identification
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
Acute Health Effects
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS:
Rat TDLo: Oral; 12600 mg/kg/6W continuous
TOXIC EFFECTS:
Tumorigenic - Neoplastic by RTECS criteria
Liver - Tumors
Tumorigenic - Facilitates action of known carcinogens
DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
Rat TDLo: Oral; 43 gm/kg; male 70D and70D prior to mating-1D after birth prior to mating.
TOXIC EFFECTS:
Effects on Newborn - Live birth index (similar to T26, except measured after birth)
Effects on Newborn - Growth statistics (e.g., reduced weight gain)
Rat TDLo: Oral; 10000 ppm; female multigeneration
TOXIC EFFECTS:
Effects on Newborn - Growth statistics (e.g., reduced weight gain)
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

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Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Continued on Next Page
Curcumin (Synthetic)

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Section V.Fire and Explosion Data
Not available.
FlammabilityMay be combustible at high temperature.Auto-Ignition
Flammable LimitsNot available.
Flash PointsNot available.
Combustion ProductsThese products are toxic carbon oxides (CO, CO2).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.

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Section VI.Accidental Release Measures
Irritating material. Possible tumorigenic material.
Spill Cleanup
In case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and excercise caution. Use a
Instructions
shovel to put material into a convenient waste disposal container. Consult federal, state and/or local authorities for
assistance on disposal.

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Section VII. Handling and Storage
Handling and StorageIRRITANT. POSSIBLE TUMORIGEN. HEAT SENSITIVE. FREEZE. Keep away from heat. Mechanical exhaust required.
When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe
Information
dust.
Always store away from incompatible compounds such as oxidizing agents.

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Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal ProtectionSplash goggles. Dust respirator. Lab coat. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

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Section IX. Physical and Chemical Properties
Solid. (Pale yellow to yellow red crystallineSolubility
Physical state @ 20°CSoluble in acetone.
powder.)
Not available.
Specific Gravity
Molecular Weight368.38Partition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot applicable.
186°C (366.8°F)Not available.
Melting PointVapor Density
Refractive IndexNot available.VolatilityNot available.
Not available.Not available.
Critical TemperatureOdor
ViscosityNot available.TasteNot available.

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Section X.Stability and Reactivity Data

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This material is stable if stored under proper conditions. (See Section VII for instructions)
Stability
Conditions of InstabilityFreeze. Heat sensitive. Avoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.

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Section XI. Toxicological Information
MI5230000
RTECS Number
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Rat LD50 (oral) 12.2gm/kg
Toxicity Data
Mouse LD50 (oral) >2000mg/kg
Mouse LD50 (ipr) 1500mg/kg
Continued on Next Page
Curcumin (Synthetic)
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS:
Rat TDLo: Oral; 12600 mg/kg/6W continuous
TOXIC EFFECTS:
Tumorigenic - Neoplastic by RTECS criteria
Liver - Tumors
Tumorigenic - Facilitates action of known carcinogens
DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
Rat TDLo: Oral; 43 gm/kg; male 70D and70D prior to mating-1D after birth prior to mating.
TOXIC EFFECTS:
Effects on Newborn - Live birth index (similar to T26, except measured after birth)
Effects on Newborn - Growth statistics (e.g., reduced weight gain)
Rat TDLo: Oral; 10000 ppm; female multigeneration
TOXIC EFFECTS:
Effects on Newborn - Growth statistics (e.g., reduced weight gain)
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
Acute Toxic Effects
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

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Section XII.Ecological Information
EcotoxicityNot available.
Environmental FateNot available.

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
PIN Number
Proper Shipping NameNot applicable.
Not applicable.
Packing Group (PG)
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
Not available.
WHMIS Classification
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin.

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SECTION 16 - ADDITIONAL INFORMATION
N/A