Remodelin

Modify Date: 2024-01-02 17:10:02

Remodelin Structure
Remodelin structure
Common Name Remodelin
CAS Number 949912-58-7 Molecular Weight 282.363
Density 1.3±0.1 g/cm3 Boiling Point 498.9±47.0 °C at 760 mmHg
Molecular Formula C15H14N4S Melting Point N/A
MSDS USA Flash Point 255.5±29.3 °C

 Use of Remodelin


Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.IC50 value:Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.

 Names

Name Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]
Synonym More Synonyms

 Remodelin Biological Activity

Description Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.IC50 value:Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
Related Catalog
References

[1]. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 498.9±47.0 °C at 760 mmHg
Molecular Formula C15H14N4S
Molecular Weight 282.363
Flash Point 255.5±29.3 °C
Exact Mass 282.093903
PSA 89.31000
LogP 2.16
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.702
Storage condition 2-8℃

 Synonyms

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-
4-[2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl]benzonitrile
4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
Remodelin