MK-8998

Modify Date: 2024-01-13 15:48:54

MK-8998 structure	Common Name	MK-8998
	CAS Number	953778-58-0	Molecular Weight	380.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₃F₃N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-8998

MK-8998 is a potent and selective antagonist of the T-type calcium channel.

Name	MK-8998
Synonym	More Synonyms

Description	MK-8998 is a potent and selective antagonist of the T-type calcium channel.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
In Vitro	MK-8998 is a potent and selective antagonist of the T-type calcium channel that is being investigated as a potential new therapy for the treatment of schizophrenia. Because MK-8998 does not block D2, 5HT2a, muscarinic, or histaminic receptors, it has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics[1].
In Vivo	MK-8998 is not effective in treating acutely psychotic inpatients with schizophrenia. There are no significant differences between either MK-8998 or olanzapine versus placebo at any time point. MK-8998 and olanzapine are generally well tolerated but are associated with a higher percentage of adverse events compared with placebo[1].
References	[1]. Egan MF, et al. Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia. Hum Psychopharmacol. 2013 Mar;28(2):124-33.

Molecular Formula	C₂₀H₂₃F₃N₂O₂
Molecular Weight	380.40

MFCD22572346

DC Chemicals Limited
China
Product Name: MK-8998
Price: $950.0/100mg $1700.0/250mg $3200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

MK-8998 suppliers

Price: $331/10mM*1mLinDMSO

Reference only. check more MK-8998 price