Pomaglumetad methionil

Modify Date: 2024-01-02 14:10:15

Pomaglumetad methionil structure	Common Name	Pomaglumetad methionil
	CAS Number	956385-05-0	Molecular Weight	384.42600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₂₀N₂O₈S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pomaglumetad methionil

Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used to treat schizophrenia[1][2].

Name	(1R,4S,5S,6S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-2,2-dioxo-2λ6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid,hydrate
Synonym	More Synonyms

Description	Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used to treat schizophrenia[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGlu2/3 receptor[1][2]
References	[1]. Adams DH, et al. A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia. BMC Psychiatry. 2013 May 22;13:143. [2]. Downing AM, et al. A Double-Blind, Placebo-Controlled Comparator Study of LY2140023 monohydrate in patients with schizophrenia. BMC Psychiatry. 2014 Dec 10;14:351.

Molecular Formula	C₁₂H₂₀N₂O₈S₂
Molecular Weight	384.42600
Exact Mass	384.06600
PSA	210.26000
LogP	0.69110

Pomaglumetad methionil

UNII-WE665JB15R

Pomaglumetad methionil

Use of Pomaglumetad methionil

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Pomaglumetad methionil Biological Activity

Chemical & Physical Properties

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