Valnivudine

Modify Date: 2025-11-28 15:03:15

Valnivudine structure	Common Name	Valnivudine
	CAS Number	956483-02-6	Molecular Weight	497.583
	Density	1.3±0.1 g/cm3	Boiling Point	667.3±65.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₅N₃O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	357.4±34.3 °C

Use of Valnivudine

Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo[1][2].

Name	[(2R,3S,5R)-3-hydroxy-5-[2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3-yl]oxolan-2-yl]methyl (2S)-2-amino-3-methylbutanoate
Synonym	More Synonyms

Description	Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	In vitro cytotoxicity studies in normal human primary hepatocytes, keratinocytes, and rapidly dividing HepG2 cells, Valnivudine (FV-100 free base) demonstrates mean 50% cytotoxic concentration values of >10 μM[2]. CF-1743 (compound 4f) has anti-varicella-zoster virus (VZV) activity in VZV OKA (EC50=0.3 nM), VZV YS (EC50=0.1 nM) in HEL cell[3].
References	[1]. Nathan B Price, et al. Progress in the development of new therapies for herpesvirus infections. Curr Opin Virol. 2011 Dec;1(6):548-54. [2]. Helen S Pentikis, et al. Pharmacokinetics and safety of FV-100, a novel oral anti-herpes zoster nucleoside analogue, administered in single and multiple doses to healthy young adult and elderly adult volunteers. Antimicrob Agents Chemother. 2011 Jun;55(6):2847-54. [3]. C McGuigan, et al. Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. J Med Chem. 2000 Dec 28;43(26):4993-7.

Density	1.3±0.1 g/cm3
Boiling Point	667.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₅N₃O₆
Molecular Weight	497.583
Flash Point	357.4±34.3 °C
Exact Mass	497.252594
PSA	129.81000
LogP	3.39
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.624

FV-100 free base

{(2R,3S,5R)-3-Hydroxy-5-[2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl]tetrahydro-2-furanyl}methyl (2S)-2-amino-3-methylbutanoate

UNII-0NJ5F6D4U7

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Valnivudine

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