HBF-0259

Modify Date: 2024-01-14 17:26:45

HBF-0259 structure	Common Name	HBF-0259
	CAS Number	957011-15-3	Molecular Weight	364.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂Cl₂FN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HBF-0259

HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis[1][2].

Name	HBF-0259

Description	HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC50=1.5 μM) in HepDE19 cells, with an CC50 of >50 μM[1]. HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells[1].
References	[1]. Dougherty AM, et, al. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. [2]. Yu W, et, al. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70.

Molecular Formula	C₁₆H₁₂Cl₂FN₅
Molecular Weight	364.20

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HBF-0259
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Purity: 99.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.