Vortioxetine (Lu AA21004) HBr

Modify Date: 2024-01-02 12:25:38

Vortioxetine (Lu AA21004) HBr structure	Common Name	Vortioxetine (Lu AA21004) HBr
	CAS Number	960203-27-4	Molecular Weight	379.358
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₃BrN₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Vortioxetine (Lu AA21004) HBr

Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Name	vortioxetine hydrobromide
Synonym	More Synonyms

Description	Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Research Areas >> Neurological Disease
Target	5-HT1A Receptor:15 nM (Ki) 5-HT1B Receptor:33 nM (Ki) 5-HT3A Receptor:3.7 nM (Ki) 5-HT7 Receptor:19 nM (Ki) SERT:1.6 nM (Ki)
In Vitro	Vortioxetine (Compound 5m) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine displays antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, agonistic properties at 5-HT1A receptors, and potent inhibition of SERT[1]. Vortioxetine is a partial h5-HT 1B receptor agonist with EC50 of 460 nM and intrinsic activity of 22% using a whole-cell cAMP-based assay. Vortioxetine binds to the r5-HT 7 receptor with a Ki value of 200 nM and is a functional antagonist at the r5-HT7 receptor with an IC50 of 2 μM in an in vitro whole-cell cAMP assay[5].
In Vivo	Vortioxetine (Lu AA21004) occupies the r5-HT1B receptor and rSERT (ED50= 3.2 and 0.4 mg/kg, respectively) after subcutaneous administration and is a 5-HT3 receptor antagonist[6]. Vortioxetine significantly increases cell proliferation and cell survival and stimulates maturation of immature granule cells in the sub granular zone of the dentate gyrus of the hippocampus after 21 days of treatment[3]. Vortioxetine does not cause cognitive or psychomotor impairment[4].
References	[1]. Bang-Andersen B, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. [2]. Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159. [3]. Theunissen EL, et al. A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501. [4]. Rothschild AJ, Mahableshwarkar AR, Jacobsen P, Vortioxetine (Lu AA21004) 5mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States. Eur Neuropsychopharmacol. 2012 Dec;22(12):858-66. [5]. Mork A, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.

Molecular Formula	C₁₈H₂₃BrN₂S
Molecular Weight	379.358
Exact Mass	378.076538
PSA	40.57000
LogP	5.21610
Storage condition	-20°C

Piperazine

CAS#:110-85-0

2,4-Dimethyliod...

CAS#:4214-28-2

2-Bromothiophenol

CAS#:6320-02-1

~84%

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S; CHRISTENSEN, Kim, Lasse Patent: WO2013/102573 A1, 2013 ; Location in patent: Page/Page column 13; 14 ;

Vortioxetine

CAS#:508233-74-7

~81%

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S Patent: WO2008/113359 A2, 2008 ; Location in patent: Page/Page column 16 ; WO 2008/113359 A2

1-[2-(2,4-DiMet...

CAS#:960203-28-5

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S Patent: WO2008/113359 A2, 2008 ; Location in patent: Page/Page column 17 ; WO 2008/113359 A2

Piperazine

CAS#:110-85-0

1-Bromo-2-iodob...

CAS#:583-55-1

2,4-Dimethylthi...

CAS#:13616-82-5

~83%

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S; CHRISTENSEN, Kim, Lasse Patent: WO2013/102573 A1, 2013 ; Location in patent: Page/Page column 14; 15 ;

4-[2-(2,4-dimet...

CAS#:960203-42-3

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S Patent: WO2007/144005 A1, 2007 ; Location in patent: Page/Page column 44-45 ; WO 2007/144005 A1

N/A

CAS#:960203-39-8

Vortioxetine (L...

CAS#:960203-27-4

Literature: H. LUNDBECK A/S Patent: WO2008/113359 A2, 2008 ; Location in patent: Page/Page column 18 ; WO 2008/113359 A2

N-O-glucoronide

CAS#:1393733-77-1

Vortioxetine (L...

CAS#:960203-27-4

4-[2-(2,4-dimet...

CAS#:1393644-67-1

Literature: Uldam, Henriette Kold; Juhl, Martin; Pedersen, Henrik; Dalgaard, Lars Drug Metabolism and Disposition, 2011 , vol. 39, # 12 p. 2264 - 2274

N-oxide/N-gluco...

CAS#:1393733-76-0

Vortioxetine (L...

CAS#:960203-27-4

4-[2-(2,4-dimet...

CAS#:1393644-67-1

Literature: Uldam, Henriette Kold; Juhl, Martin; Pedersen, Henrik; Dalgaard, Lars Drug Metabolism and Disposition, 2011 , vol. 39, # 12 p. 2264 - 2274

2-[(2,4-Dimethy...

CAS#:1019453-85-0

Vortioxetine (L...

CAS#:960203-27-4

4-[2-(2,4-dimet...

CAS#:1393644-67-1

Literature: Uldam, Henriette Kold; Juhl, Martin; Pedersen, Henrik; Dalgaard, Lars Drug Metabolism and Disposition, 2011 , vol. 39, # 12 p. 2264 - 2274

Brintellix

1-{2-[(2,4-Dimethylphenyl)sulfanyl]phenyl}piperazine hydrobromide (1:1)

Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-, hydrobromide (1:1)

UNII:TKS641KOAY

VORTIOXETINE HBr

Vortioxetine hydrobromide

vortioxetine monohydrobromide

1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine monohydrobromide

1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazinehydrobromide

1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine hydrobromide

Vortioxetine (hydrobromide)

DC Chemicals Limited
China
Product Name: Vortioxetine hydrobromide
Price: $350.0/100mg $700.0/250mg $1300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vortioxetine hydrobromide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Vortioxetine hydrobromide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Vortioxetine Hydrobromide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Vortioxetine (Lu AA21004) HBr suppliers

Price: $92/10mM*1mLinDMSO

Reference only. check more Vortioxetine (Lu AA21004) HBr price

Vortioxetine (Lu AA21004) HBr

Use of Vortioxetine (Lu AA21004) HBr

Names

Vortioxetine (Lu AA21004) HBr Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms