Neurokinin A(4-10)

Modify Date: 2024-01-05 15:29:41

Neurokinin A(4-10) Structure
Neurokinin A(4-10) structure
Common Name Neurokinin A(4-10)
CAS Number 97559-35-8 Molecular Weight 766.90500
Density 1.276g/cm3 Boiling Point 1231.2ºC at 760mmHg
Molecular Formula C34H54N8O10S Melting Point N/A
MSDS N/A Flash Point 698.4ºC

 Use of Neurokinin A(4-10)


Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.

 Names

Name neurokinin a (4-10)
Synonym More Synonyms

 Neurokinin A(4-10) Biological Activity

Description Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.
Related Catalog
Target

NK2 receptor[1]

In Vitro Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].
References

[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

 Chemical & Physical Properties

Density 1.276g/cm3
Boiling Point 1231.2ºC at 760mmHg
Molecular Formula C34H54N8O10S
Molecular Weight 766.90500
Flash Point 698.4ºC
Exact Mass 766.36800
PSA 326.54000
LogP 1.25010
Index of Refraction 1.565

 Synonyms

ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
DSFVGLM-NH2
L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH2
NKA(4-10)
A-NEUROKININ FRAGMENT 4-10
H-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
Neurokinin A(4-10)
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