N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

Modify Date: 2025-08-25 18:30:16

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea structure	Common Name	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
	CAS Number	97627-24-2	Molecular Weight	261.70700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₂ClN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphenyl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.

Name	1-(2-chloro-6-methylphenyl)-3-pyridin-4-ylurea
Synonym	More Synonyms

Description	N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphenyl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Compound shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg. The activity seen with 30 mg/kg 37 is still present 4 h postdose. Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound is selected for clinical trials[1].
Animal Admin	Mice: Five mice are tested at each of three doses (30,100, and 300 mg/kg) and three times (0.5, 2, and 4 h). The mice are subjected to electrical current delivered through ear clips for 0.2 s (90 mA, 1-ms monophasic pulses at 100 Hz). This current strength is approximately 4 times that required to produce seizures in 99% of mice and reliably produce seizures in 100% of control mice. Prevention of tonic hind limb extension is taken as an anticonvulsant effect. Behavioral side effects are measured in mice[1].
References	[1]. Pavia MR, et al. N-Phenyl-N'-pyridinylureas as Anticonvulsant Agents. J. Med. Chem. 1990,33, 854-861

Molecular Formula	C₁₃H₁₂ClN₃O
Molecular Weight	261.70700
Exact Mass	261.06700
PSA	60.74000
LogP	3.12290
InChIKey	ZSBWDKCIIZYQIR-UHFFFAOYSA-N
SMILES	Cc1cccc(Cl)c1NC(=O)Nc1ccncc1

4-AMINOPYRIDINE

CAS#:504-24-5

2-CHLORO-6-METH...

CAS#:40398-01-4

~78%

N-(2-Chloro-6-m...

CAS#:97627-24-2

Literature: Pavia; Lobbestael; Taylor; Hershenson; Miskell Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 854 - 861

Precursor 2
CAS#:504-24-5 4-AMINOPYRIDINE CAS#:40398-01-4 2-CHLORO-6-METH...
DownStream 0

Name: Anticonvulsant activity against tonic extension produced by maximal electroshock in m...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL739193

Name: The compound was tested for Ataxia(ATAX) by the inverted screen test, after oral admi...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL741479

Name: The compound was tested for protective activity against Maximal Electroshock seizures...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL740747

Name: Protective activity was determined against Maximal Electroshock seizures(MES) in mous...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL736813

Name: Protective activity was determined against Maximal Electroshock seizures(MES) in rat ...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL883297

Name: The compound was tested for Ataxia(ATAX) by the inverted screen test, after intraperi...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL741477

Name: The compound was tested for Ataxia(ATAX) by the inverted screen test, after intraperi...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL783837

Name: Anticonvulsant activity against tonic extension produced by maximal electroshock in m...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL743105

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Urea,N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl

N-(2-CHLORO-6-METHYLPHENYL)-N'-(PYRIDIN-4-YL)UREA

N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl urea

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

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N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.