Penciclovir Sodium
Modify Date: 2024-04-05 09:21:28
Penciclovir Sodium structure
|
Common Name | Penciclovir Sodium | ||
|---|---|---|---|---|
| CAS Number | 97845-62-0 | Molecular Weight | 275.24000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H14N5NaO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Penciclovir SodiumPenciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2]. |
| Name | sodium,4-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate |
|---|---|
| Synonym | More Synonyms |
| Description | Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2]. |
|---|---|
| Related Catalog | |
| Target |
HSV-1:0.5 μg/mL (EC50) HSV-2:0.8 μg/mL (EC50) |
| In Vitro | Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1]. Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells Concentration: 0-100 µg/ml Incubation Time: Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively. |
| In Vivo | Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2]. Animal Model: Three-week-old female Balb/c mice[2] Dosage: 100 mg/kg Administration: S.c.; daily for 5 days Result: Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice. |
| References |
| Molecular Formula | C10H14N5NaO3 |
|---|---|
| Molecular Weight | 275.24000 |
| Exact Mass | 275.09900 |
| PSA | 132.88000 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
|
| HS Code | 2933990090 |
|---|
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine monosodium salt |
| 2-Amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt |
| Penciclovir cream |
| Penciclovir sodium [USAN] |
| Penciclovir sodium |
| 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt |