Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)

Modify Date: 2024-01-07 12:06:50

Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1) structure	Common Name	Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)
	CAS Number	985-13-7	Molecular Weight	431.95200
	Density	1.104g/cm3	Boiling Point	527.1ºC at 760 mmHg
	Molecular Formula	C₂₄H₃₀ClNO₄	Melting Point	187ºC
	MSDS	N/A	Flash Point	185.9ºC

Use of Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)

Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].

Name	ethaverine hydrochloride
Synonym	More Synonyms

Description	Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
In Vitro	Ethaverine hydrochloride (10 μM，PC12 细胞) 通过阻断 L 型电压敏感 Ca2+ 通道来减少儿茶酚胺分泌[2]。 Ethaverine hydrochloride (12 h) 通过抑制 PC12 细胞中的酪氨酸羟化酶 (TH) 活性来降低多巴胺含量，IC50 为 1.4 μM[3]。 Ethaverine hydrochloride 抑制小鼠脑中的单胺氧化酶 (MAO) (分离自小鼠全脑) 活性，IC50 为 25.5 μM[6]。
In Vivo	Ethaverine hydrochloride (2-10 mg/kg，静脉滴注，i.v.) 引起豚鼠耳蜗内电位显着升高[4]。 Ethaverine (1-10 mg/kg，静脉注射) 抑制麻醉狗的房室传导和心率[5]。 Animal Model: Dog[5] Dosage: 1 and 10 mg/kg Administration: i.v. Result: Inhibited atrioventricular conduction and heart rate.
References	[1]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. [2]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. [3]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. [4]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. [5]. Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. [6]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40.

Density	1.104g/cm3
Boiling Point	527.1ºC at 760 mmHg
Melting Point	187ºC
Molecular Formula	C₂₄H₃₀ClNO₄
Molecular Weight	431.95200
Flash Point	185.9ºC
Exact Mass	431.18600
PSA	49.81000
LogP	6.22240

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NW7524100

CHEMICAL NAME :: Isoquinoline, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-, hydrochloride

CAS REGISTRY NUMBER :: 985-13-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H29-N-O4.Cl-H

MOLECULAR WEIGHT :: 432.00

WISWESSER LINE NOTATION :: T66 CNJ B1R CO2 DO2& HO2 FO2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 5,69,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 86 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 9,585,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5434 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)

RIDADR	UN 3249
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Isoquinoline,1-(3,4-diethoxybenzyl)-6,7-diethoxy-,hydrochloride

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Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)

Use of Isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride (1:1)

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