Synlett

A Mild and Versatile Synthesis of Thioamides

KA Mahammed, VP Jayashankara, NP Rai, KM Raju…

Index: Mahammed; Jayashankara; Premsai Rai; Mohana Raju; Arunachalam Synlett, 2009 , # 14 p. 2338 - 2340

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Citation Number: 7

Abstract

Abstract Aliphatic and aromatic nitriles react with thioacetic acid in the presence of calcium hydride to give the corresponding thioamides in good to excellent yields. The examples studied include haloaryl nitriles in which the halogen is facile towards SN Ar reactions under other conditions.

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