Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone esters

S Liu, H Liu, W Yan, L Zhang, N Bai, CT Ho

Index: Liu, Shouxin; Liu, He; Yan, Weiying; Zhang, Li; Bai, Naisheng; Ho, Chi-Tang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 8 p. 2783 - 2789

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Citation Number: 27

Abstract

The extracts of Inula britannica have anti-inflammatory, anti-bacterial, anti-hepatitic, and anti- tumor activities. Various sesquiterpene lactones with cytotoxic properties including 1-O- acetylbritannilactone (1) have been isolated from this Chinese medicinal plant. Eight derivatives of 1-O-acetylbritannilactone,(2-O-alkyloxime-3-phenyl)-propionyl-1-O- acetylbritannilactone esters were designed and synthesized. Four of these compounds ...