Tetrahedron

Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation

C Mukherjee, D Zhu, ER Biehl, RR Parmar, L Hua

Index: Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Parmar, Rajiv R.; Hua, Ling Tetrahedron, 2006 , vol. 62, # 26 p. 6150 - 6154

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Citation Number: 22

Abstract

To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids were the major products. Unexpectedly, amides were found to be the ...

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