New efficient approach for the synthesis of 2??alkyl (aryl) substituted 4H??pyrido [1, 2??a] pyrimidin??4??ones

HG Bonacorso, FJ Righi, IR Rodrigues…

Index: Bonacorso, Helio G.; Righi, Fernando J.; Rodrigues, Isadora R.; Cechinel, Cleber A.; Costa, Michelle B.; Wastowski, Arci D.; Martins, A. P. Marcos; Zanatta, Nilo Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 1 p. 229 - 233

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Citation Number: 16

Abstract

A new, efficient and easy route for the preparation of a series of 2-alkyl (aryl) substituted 4- oxo-4H-pyrido-[1, 2-a] pyrimidines, where alkyl= CH3; aryl= C6H5, 4-FC6H4, 4-ClC6H4, 4- BrC6H4, 4-CH3C6H4, 4-OCH3-C6H4, 4-NO2C6H4 in 45–80% yield from the reaction of β- alkoxyvinyl trichloromethyl ketones with 2-aminopyridine under mild conditions, is then reported.