Antibacterial activity of a series of N 2, N 4-disubstituted quinazoline-2, 4-diamines

KS Van Horn, WN Burda, R Fleeman…

Index: Van Horn, Kurt S.; Burda, Whittney N.; Fleeman, Renee; Shaw, Lindsey N.; Manetsch, Roman Journal of Medicinal Chemistry, 2014 , vol. 57, # 7 p. 3075 - 3093

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Citation Number: 17

Abstract

A series of N 2, N 4-disubstituted quinazoline-2, 4-diamines has been synthesized and tested against multidrug resistant Staphylococcus aureus. A structure–activity and structure– property relationship study was conducted to identify new hit compounds. This study led to the identification of N 2, N 4-disubstituted quinazoline-2, 4-diamines with minimum inhibitory concentrations (MICs) in the low micromolar range in addition to favorable ...

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