Synthesis of 2-Amino-1-indanone from DL-Phenylalanine

R Zhao, P Guo, J Dong, X Zhang, X Sun…

Index: Zhao, Rong; Guo, Peijiang; Dong, Junyu; Zhang, Xiaoping; Sun, Xiaofei; Tian, Yun; Zeng, Qingle Organic Preparations and Procedures International, 2011 , vol. 43, # 4 p. 377 - 380

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Citation Number: 3

Abstract

2-Amino-1-indanone is a cyclic vicinal amino ketone. Such compounds are of great interest as pharmaceutical agents and as intermediates in natural product synthesis. 1–3 There are four main methods to synthesize this compound. One is an anionic cyclization of N-protected o-bromophenylalanine ester by lithium-bromine exchange followed by internal trapping of the lithiated intermediate by the carboxylate group under rigorously anhydrous, anaerobic ...