… on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic …

K Hayashi, K Nunami, J Kato, N Yoneda…

Index: Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297

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Citation Number: 75

Abstract

(4S)-l-Alkyl-3-[[N-(carboxyalkyl) amino] acyl]-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods. Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed. The dicarboxylic acids 3a-n possessing S, S, S configuration showed potent in vitro ACE inhibitory activities with IC, o values of 1.1 X 10-8-1.5 X M. The ...