Iridium− Monodentate Phosphoramidite-Catalyzed Asymmetric Hydrogenation of Substituted Benzophenone N− H Imines

…, R Tao, Y Sun, X Zhang, F Gosselin

Index: Hou, Guohua; Gosselin, Francis; Li, Wei; McWilliams, J. Christopher; Sun, Yongkui; Weisel, Mark; O'Shea, Paul D.; Chen, Cheng-Yi; Davies, Ian W.; Zhang, Xumu Journal of the American Chemical Society, 2009 , vol. 131, # 29 p. 9882 - 9883

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Citation Number: 64

Abstract

Homogeneous asymmetric hydrogenation of unprotected benzophenone N− H imines 1a− r using Ir−(S)-N-benzyl-N-methyl-MonoPhos as a catalyst provides chiral amines 2a− r in 80− 96% yield with enantioselectivities up to 98% ee (18 examples) for ortho-substituted substrates.

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