Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human …

H Miyachi, M Nomura, T Tanase, Y Takahashi…

Index: Miyachi, Hiroyuki; Nomura, Masahiro; Tanase, Takahiro; Takahashi, Yukie; Ide, Tomohiro; Tsunoda, Masaki; Murakami, Koji; Awano, Katsuya Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 1 p. 77 - 80

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Citation Number: 41

Abstract

A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure–activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.