Deamination of 2-Aminothiazoles and 3-Amino-1, 2, 4-triazines with Nitric Oxide in the Presence of a Catalytic Amount of Oxygen.

T Itoh, Y Matsuya, K Nagata, A OHSAWA

Index: Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Ohsawa, Akio Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1547 - 1549

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Citation Number: 4

Abstract

1548 Vol. 45, No. 9 in low yield because of the instability of the thioformamide under acidic conditions. On the contrary, of all the methods described for the formation of thiazole rings, the most efficient involves formation of 2-aminothiazoles.8 Therefore an alternative method for thiazole synthesis comprises deamination of la with nitrous acid and hypophosphorus acid (13%),9 and with amyl nitrite in THF (16%),10 but the reaction yields and reproducibilities are quite ...

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