Tetrahedron

Target-oriented synthesis: miscellaneous synthetic routes to access 1, 4-enediones through the coupling of 1, 3-dicarbonyl compounds with multiform substrates

Y Zhu, Q Cai, Q Gao, F Jia, M Liu, M Gao, A Wu

Index: Zhu, Yan-Ping; Cai, Qun; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Meng; Wu, An-Xin Tetrahedron, 2013 , vol. 69, # 31 p. 6392 - 6398

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Citation Number: 11

Abstract

Target-oriented synthetic protocol was presented for the synthesis of 1, 4-enediones. The approach can efficiently construct 1, 4-enediones through different reaction pathways from multiform substrates α-halo aromatic ketones, 2-hydroxy-aromatic ketones and methyl carbinols. In this reaction, CuI was found to be the most efficient catalyst. Multiform substrates were also found to perform well to afford the products in a one-pot fashion.

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