Synthesis, Biological Evaluation, WAC and NMR Studies of S??Galactosides and Non??Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate …

J Ramos??Soriano, U Niss, J Angulo…

Index: Ramos-Soriano, Javier; Niss, Ulf; Angulo, Jesus; Angulo, Manuel; Moreno-Vargas, Antonio J.; Carmona, Ana T.; Ohlson, Sten; Robina, Inmaculada Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17989 - 18003

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Citation Number: 3

Abstract

Abstract The synthesis of several non-carbohydrate ligands of cholera toxin based on polyhydroxyalkylfuroate moieties is reported. Some of them have been linked to D-galactose through a stable and well-tolerated S-glycosidic bond. They represent a novel type of non- hydrolyzable bidentate ligand featuring galactose and polyhydroxyalkylfuroic esters as pharmacophoric residues, thus mimicking the GM1 ganglioside. The affinity of the new ...