Tetrahedron

A new and expeditious strategy for the synthesis of β-amino acids from Δ 2-oxazolines

S Fustero, MD Dı́az, A Navarro, E Salavert, E Aguilar

Index: Fustero, Santos; Diaz, Ma Dolores; Navarro, Antonio; Salavert, Esther; Aguilar, Enrique Tetrahedron, 2001 , vol. 57, # 4 p. 703 - 712

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Citation Number: 8

Abstract

A new, mild two-step synthesis of racemic β-amino acids starting from 2-alkyl-Δ2-oxazolines is described. The process implies the initial formation of masked N-substituted or N- unsubstituted β-enamino acid derivatives followed by chemoselective reduction of the enamino moiety. The process takes place with high yields, total chemoselectivity and moderate diastereoselectivity.

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