Aqueous??Mediated N??Alkylation of Amines

CB Singh, V Kavala, AK Samal…

Index: Singh, Chingakham B.; Kavala, Veerababurao; Samal, Akshaya K.; Patel, Bhisma K. European Journal of Organic Chemistry, 2007 , # 8 p. 1369 - 1377

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Citation Number: 30

Abstract

Abstract Direct N-alkylation of primary amines to secondary/tertiary amines and of secondary amines to tertiary amines has been achieved in excellent yields by employing alkyl, benzylic and allylic halides in the presence of NaHCO 3 in an aqueous medium at an elevated temperature. Amines of differentstereoelectronic nature react with ease with different halides. The selective formation of secondary amines and the formation of three different ...

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