Mechanism-based inactivation of N-arylhydroxamic acid N, O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes

VC Marhevka, NA Ebner, RD Sehon…

Index: Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24

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Citation Number: 27

Abstract

N-Arylhydroxamic acid N, O-acyltransferase (AHAT) catalyzes the transfer of the N-acetyl group from N-arylhydroxamic acids to arylamines. In the absence of an arylamine acceptor, AHAT catalyzes the conversion of N-arylhydroxamic acids to reactive electrophilic intermediates that become irreversibly bound to cellular nucleophiles, including those present on AHAT itself. As part of an investigation of the AHAT-catalyzed bioactivation ...