Synthesis and radioprotective properties of pulvinic acid derivatives

…, S Meunier, T Le Gall, JM Denis, P Bischoff…

Index: Leroux, Antoine; Meunier, Stephane; Legall, Thierry; Denis, Jean-Marc; Bischoff, Pierre; Wagner, Alain ChemMedChem, 2011 , vol. 6, # 3 p. 561 - 569

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Citation Number: 6

Abstract

Abstract A high-throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton-like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell-based fluorescent assay, we show that some of these compounds have a pronounced ...