1-(Alkyl/Arylthiocarbamoyl) benzotriazoles as stable isothiocyanate equivalents: synthesis of di-and trisubstituted thioureas

AR Katritzky, S Ledoux, RM Witek…

Index: Katritzky, Alan R.; Ledoux, Stephane; Witek, Rachel M.; Nair, Satheesh K. Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 2976 - 2982

Full Text: HTML

Citation Number: 49

Abstract

1-(Alkyl/arylthiocarbamoyl) benzotriazoles 4a-i were synthesized in yields of 91-99% from bis (benzotriazolyl) methanethione (3). Reagents 4a-g were then used as isothiocyanate equivalents for the efficient synthesis of 10 secondary and 14 tertiary thioureas in high- yielding, convenient processes.