1, 4-Diazabicyclo [2.2. 2] octanes and 1, 5-Diazabicyclo [3.2. 2] nonanes from Piperazines and Homopiperazines

SM McElvain, LW Bannister

Index: McElvain; Bannister Journal of the American Chemical Society, 1954 , vol. 76, p. 1126,1129

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Abstract

Thc introduction of an ethylene bridge between the nitrogens of 2, 2, 5, 5- tetramethylpiperazine, homopiperazinc arld 22-dimethylhomopiperazine to form the bicyclo compounds XIX, XX and XXI has been effected by the pyrolysis of the hpdrobromide salts of the l-(2-bromoethyl) derivatives (VIII, XV, XVII) of these monocyclic compounds. The presence of thc gem-dimethyl groups in VI11 severely hinders this bridging reaction so ...