Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

…, J Castro-Garza, BD Mata-Cardenas, F Naqvi…

Index: Bharti, Neelam; Husain, Kakul; Gonzalez Garza; Cruz-Vega, Delia E; Castro-Garza; Mata-Cardenas, Benito D; Naqvi, Fehmida; Azam, Amir Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 23 p. 3475 - 3478

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Citation Number: 61

Abstract

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

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