Journal of Medicinal Chemistry

5-Isonitrosorhodanines

FC Brown, CM Harris, F Perry

Index: Brown,F.C. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1239 - 1243

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Citation Number: 7

Abstract

3-Substituted rhodanines were converted to their 5-isonitroso derivatives bx reaction with isopropyl nitrite and hydrochloric acid. The 3-benzyl-5-isonitrosorhodanines, which contain a chlorine substituent in the para position of the benzyl group, show a considerable increase in fungistatic activity over the corresponding 3-chlorinated benxylrhodanine while the accompanying loss in bacteriostatic activity is relatively slight. Such enhancement is not ...