Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase

P Thanigaimalai, KC Lee, VK Sharma, C Joo…

Index: Thanigaimalai, Pillaiyar; Lee, Ki-Cheul; Sharma, Vinay K.; Joo, Cheonik; Cho, Won-Jea; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6824 - 6828

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Citation Number: 11

Abstract

Effect of a series of 1-phenylthioureas 1a–k and 1, 3-disubstituted thioureas 2a–k were evaluated against melanin formation in melanoma B16 cell line and mushroom tyrosinase. Inhibitory activity of tyrosinase of 1-phenylthioureas 1a–k is parallel to their melanogenic inhibition. Thus, the melanogenic inhibition in melanoma B16 cells of 1-phenylthioureas could be the result of inhibition of tyrosinase. However, 1, 3-diaryl or 1-phenyl-3- ...