Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method

LN Burgula, K Radhakrishnan, LM Kundu

Index: Burgula, Laxmi Narayana; Radhakrishnan; Kundu, Lal Mohan Tetrahedron Letters, 2012 , vol. 53, # 21 p. 2639 - 2642

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Citation Number: 12

Abstract

Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6- methyluracil and 6-phenyluracil were also determined.