Biosynthesis of the hypotensive metabolite oudenone by Oudemansiella radicata. 1. Intact incorporation of a tetraketide chain elongation intermediate

YS Tsantrizos, F Zhou, P Famili…

Index: Tsantrizos, Youla S.; Zhou, Fei; Famili, Parsa; Yang, Xianshu Journal of Organic Chemistry, 1995 , vol. 60, # 21 p. 6922 - 6929

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Citation Number: 22

Abstract

The biosynthesis of the fungal metabolite oudenone (1) was investigated in cultures of Oudemamiella radicata. Feeding experiments using 13C-and 2H-labeled precursors, as well as NMR analyses of the labeled metabolite, suggested a polyketide origin. The incorporation of six acetate units into the carbon skeleton of 1 was observed when cultures were fed the N-acetylcysteamine thioester derivative of 13C-labeled acetate. Labeling of ...