Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2 (1H)-ones as potential TACE inhibitors: design, synthesis, molecular modeling, and preliminary …

S DasGupta, PR Murumkar, R Giridhar…

Index: DasGupta, Shirshendu; Murumkar, Prashant R.; Giridhar, Rajani; Yadav, Mange Ram Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3604 - 3617

Full Text: HTML

Citation Number: 25

Abstract

Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2 (1H)- ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the ...

Related Articles:

Utilization of Alkoxy Ketones in the Synthesis of Quinolines by the Pfitzinger Reaction. II1

[Lesesne; Henze Journal of the American Chemical Society, 1942 , vol. 64, p. 1897,1898]

Justus Liebig's Annalen Der Chemie. Über die Einwirkung des Ozons auf organische Verbindungen

[Doebner Justus Liebigs Annalen der Chemie, 1887 , vol. 242, p. 265 Justus Liebigs Annalen der Chemie, 1888 , vol. 249, p. 98]

Utilization of Alkoxy Ketones in the Synthesis of Quinolines by the Pfitzinger Reaction. II1

[Lesesne; Henze Journal of the American Chemical Society, 1942 , vol. 64, p. 1897,1898]

More Articles...