Synthesis and biological evaluation of thiophene [3, 2-b] pyrrole derivatives as potential anti-inflammatory agents

…, MP Kumar, VK Reddy, T Suresh, P Hegde

Index: Rajender Kumar; Raju; Satish Goud; Sailaja; Sarma; Om Reddy; Prem Kumar; Krishna Reddy; Suresh; Hegde, Pragathi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1221 - 1230

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Citation Number: 63

Abstract

A series of thiophene [3, 2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3, 2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 ...